Tyk2-IN-7

MedChem Express

Tyk2-IN-7 [1609391-90-3]

10

1609391-90-3

Research Use Only

99.62

C18H15D3N6O3S

401.46

Tyk2-IN-7 is a TYK2 JH2 inhibitor, binds to TYK2 JH2 domain with IC50 and Ki.app of 0.00053 microM and 0.00007 microM, respectively. Tyk2-IN-7 provides a highly selective alternative to conventional TYK2 orthosteric inhibitors, inhibits TYK2/JAK1/JAK2 kinase domain. Tyk2-IN-7 provides robust inhibition in a mouse IL-12-induced IFNgamma pharmacodynamic model as well as efficacy in an IL-23 and IL-12-dependent mouse colitis model[1].

O=C(NC([2H])([2H])[2H])C1=NN=C(NC2=CC=CC=N2)C=C1NC3=CC=CC=C3S(=O)(C)=O

2°C to 8°C

12352200