Tyrosine Hydroxylase antibody [185]

GTX10372

ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse, Rat

TargetTh

Overview

Supplier
GeneTex
Product Name
Tyrosine Hydroxylase antibody [185]
Delivery Days Customer
9
Application Supplier Note
WB: 1:25-1:50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
185
Conjugate
Unconjugated
Gene ID21823
Target name
Th
Target description
tyrosine hydroxylase
Target synonyms
tyrosine 3-monooxygenase, tyrosine 3-hydroxylase
Host
Mouse
Isotype
IgG2a
Protein IDP24529
Protein Name
Tyrosine 3-monooxygenase
Scientific Description
The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
Reactivity
Human, Mouse, Rat
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

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Cao Q, Luo S, Yao W, et al. Suppression of abnormal α-synuclein expression by activation of BDNF transcription ameliorates Parkinson's disease-like pathology. Mol Ther Nucleic Acids. 2022,29:1-15. doi: 10.1016/j.omtn.2022.05.037
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Chen C, Ma Q, Deng P, et al. Critical role of TRPC1 in thyroid hormone-dependent dopaminergic neuron development. Biochim Biophys Acta Mol Cell Res. 2017,1864(10):1900-1912. doi: 10.1016/j.bbamcr.2017.07.019
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Plummer NW, Scappini EL, Smith KG, et al. Two Subpopulations of Noradrenergic Neurons in the Locus Coeruleus Complex Distinguished by Expression of the Dorsal Neural Tube Marker Pax7. Front Neuroanat. 2017,11:60. doi: 10.3389/fnana.2017.00060
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Robertson SD, Plummer NW, Jensen P. Uncovering diversity in the development of central noradrenergic neurons and their efferents. Brain Res. 2016,1641(Pt B):234-44. doi: 10.1016/j.brainres.2015.11.023
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Plummer NW, Evsyukova IY, Robertson SD, et al. Expanding the power of recombinase-based labeling to uncover cellular diversity. Development. 2015,142(24):4385-93. doi: 10.1242/dev.129981
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