UBE2N Antibody, Biotin conjugated

Cusabio

UBE2N Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

UBE2N

ubiquitin conjugating enzyme E2 N

bendless-like ubiquitin conjugating enzyme; E2 ubiquitin-conjugating enzyme N; epididymis secretory protein Li 71; HEL-S-71; UBC13; UbcH13; UbcH-ben; UBCHBEN; UBC13; ubiquitin carrier protein N; ubiquitin conjugating enzyme E2N; ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (homologous to yeast UBC13); ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-protein ligase N; yeast UBC13 homolog

Rabbit

IgG

Ubiquitin-conjugating enzyme E2 N

The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical \Lys-63\-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the \Lys-63\-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the \Lys-63\-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate \Lys-63\-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.

Human

-20°C or -80°C

12352203