UCK2 Inhibitor-3

MedChem Express

UCK2 Inhibitor-3

10

Research Use Only

C19H13BrFN5O2S

474.31

UCK2 Inhibitor-3 is a non-competitive inhibitor of uridine-cytidine kinase 2 ( UCK2 , a pyrimidine salvage enzyme) with an IC 50 value of 16.6 microM. UCK2 can replace dihydroorotate dehydrogenase ( DHODH ), in a certain extent, in infected or rapidly dividing cells to continue efficient uridine salvage. UCK2 Inhibitor-3 also inhibits DNA polymerase eta and kappa with IC 50 s of 56 microM and 16 microM [1] .

O=C(NC1=CC=C(Br)C=C1)CSC(N=C2C3=CNN2C4=CC=C(F)C=C4)=NC3=O

12352200