UCM-13369 [2921944-77-4]

TargetMol Chemicals

UCM-13369 [2921944-77-4]

16

Research Use Only

C25H31N3O

389.53

UCM-13369 (Compound 4b) serves as an NPM1 inhibitor, effectively downregulating the pathway linked to mutant NPM1 C+ by specifically targeting the C-terminal DNA-binding domain of NPM1 C+. It induces apoptosis in AML cell lines and primary cells, making it a valuable tool for AML research [1].

C(CNCC1CC1)[C@@H]2C3=C(C[C@@H]([C@H]2N)C4=CC=C(OC)C=C4)NC=5C3=CC=CC5

-20°C

12352200