UHRF1 antibody [1H9-D3-E11]

GeneTex

UHRF1 antibody [1H9-D3-E11]

9

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry

Research Use Only

Monoclonal

1H9-D3-E11

Unconjugated

Liquid

UHRF1

ubiquitin like with PHD and ring finger domains 1

E3 ubiquitin-protein ligase UHRF1; hNP95; hUHRF1; huNp95; ICBP90; inverted CCAAT box-binding protein of 90 kDa; Np95; nuclear phosphoprotein 95; nuclear protein 95; nuclear zinc finger protein Np95; RING finger protein 106; RING-type E3 ubiquitin transferase UHRF1; RNF106; TDRD22; transcription factor ICBP90; ubiquitin-like PHD and RING finger domain-containing protein 1

Mouse

IgG2b

E3 ubiquitin-protein ligase UHRF1

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203