ULK1 Antibody, FITC conjugated

Cusabio

ULK1 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

Liquid

ULK1

unc-51 like autophagy activating kinase 1

ATG1; ATG1 autophagy related 1 homolog; ATG1A; autophagy-related protein 1 homolog; hATG1; serine/threonine-protein kinase ULK1; UNC51; Unc51.1

Rabbit

IgG

Serine/threonine-protein kinase ULK1

Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. May also phosphorylate SESN2 and SQSTM1 to regulate autophagy (PubMed:25040165).

Human

-20°C or -80°C

12352203