Umbellulone [546-78-1]

Name: Umbellulone [546-78-1]
SKU: AG-CN2-0085_A27
Price: 1104 EUR
Availability: BackOrder

AG-CN2-0085

CAS Number546-78-1

Product group Chemicals

Estimated Purity>98%

Molecular Weight150.2

Overview

Supplier
AdipoGen Life Sciences
Product Name
Umbellulone [546-78-1]
Delivery Days Customer
10
CAS Number
546-78-1
Certification
Research Use Only
Estimated Purity
>98%
Molecular Formula
C10H14O
Molecular Weight
150.2
Scientific Description
Chemical. CAS: 546-78-1. Formula: C10H14O. MW: 150.2. Isolated from Umbellularia californica Nutt. Offensive principle of the so-called headache tree. Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine. - Offensive principle of the so-called headache tree. Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitonin gene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine.
SMILES
CC(C)C12CC1C(C)=CC2=O
Storage Instruction
2°C to 8°C,-20°C
UNSPSC
12352200

Umbellulone modulates TRP channels: J. Zhong, et al.; Pflugers Arch. 462, 861 (2011)
The 'headache tree' via umbellulone and TRPA1 activates the trigeminovascular system: R. Nassini, et al.; Brain 135, 376 (2012)
Activation of TRPA1 on dural afferents: a potential mechanism of headache pain: R.M. Edelmayer, et al.; Pain 153, 1949 (2012)