Unesbulin (PTC596)

Selleck Chemicals

Unesbulin (PTC596) [1610964-64-1]

9

Research Use Only

...

Unesbulin (PTC596) is a second-generation BMI-1 inhibitor that accelerates BMI-1 degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis. IC50 values at 72 hours ranged from 68 to 340 nM in mantle cell lymphoma (MCL) cell lines.

51202000