UPF1 Polyclonal Antibody

Reddot Biotech

UPF1 Polyclonal Antibody

5

1 mg/ml

UPF1

UPF1 RNA helicase and ATPase

ATP-dependent helicase RENT1; delta helicase; HUPF1; nonsense mRNA reducing factor 1; NORF1; pNORF1; regulator of nonsense transcripts 1; RENT1; smg-2; smg-2 homolog, nonsense mediated mRNA decay factor; UPF1 regulator of nonsense transcripts homolog; up-frameshift mutation 1 homolog; up-frameshift suppressor 1 homolog; UTF; yeast Upf1p homolog

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. Alternative splicing results in multiple transcript variants.

-20°C

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