Uroplakin 1B Antibody / UPK1B

Biorbyt

Uroplakin 1B Antibody / UPK1B

16

ImmunoHistoChemistry

Immunohistochemistry (FFPE): 1-2ug/ml IHC-P

Research Use Only

UPK1B/3081

IgG

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. UPK1B is expressed by terminally differentiated urothelial cells.

12352203