Urotensin-II receptor antagonist-1

MedChem Express

Urotensin-II receptor antagonist-1

5

Research Use Only

Urotensin-II receptor antagonist-1 (compound 1) is a low oral bioavailability (F=0-3%, rat) selective human Urotensin II receptor antagonist, K i =16 nM (test on HEK293 cells expressing recombinant human UT receptor). Urotensin-II receptor antagonist-1 inhibits cytochrome P450 ( IC 50 =0.75 microM, CYP2D6 ; 1.4 microM, CYP3A4 ), inhibits kappa-opioid receptor ( EC 50 =3.2 microM), targets cardiac sodium channels (K i =2.5 microM) [1] .

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