USP28-IN-3

TargetMol Chemicals

USP28-IN-3

65

2931509-14-5

Chemical

USP28-IN-3

C23H20Cl2N2O3S

475.39

USP28-IN-3 is a selective USP28 inhibitor (IC50 = 0.1 uM) that preferentially inhibits USP28 over USP2, USP7, USP8, USP9x, UCHL3, and UCHL5. It exhibits cytotoxic effects on cancer cells and reduces the cellular levels of c-Myc via the ubiquitin-proteasome pathway. Additionally, USP28-IN-3 lowers ankyrase-1/2 levels in vitro and increases the sensitivity of colorectal cancer cells to the chemotherapy drug Regorafenib [1].

3 years

#Reference to error in column [smiles]

-20°

12352200