USP28-IN-4

MedChem Express

USP28-IN-4

5

Research Use Only

99.35

C22H18Cl2N2O3S

461.36

USP28-IN-4 is a USP28 inhibitor (IC50=0.04 microM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1].

CS(=O)(C1=CC=C(C(Cl)=C1)C(NC2=CC=C(C(C3=CC4=C(CNC4)C=C3)=C2)Cl)=O)=O

2°C to 8°C

12352200