USP5 Antibody, Biotin conjugated

Cusabio

USP5 Antibody, Biotin conjugated

20

ELISA

Research Use Only

Polyclonal

Biotin

USP5

ubiquitin specific peptidase 5

deubiquitinating enzyme 5; isopeptidase T; ISOT; testicular tissue protein Li 218; ubiquitin carboxyl-terminal hydrolase 5; ubiquitin isopeptidase T; ubiquitin specific protease 5 (isopeptidase T); ubiquitin thioesterase 5; ubiquitin thiolesterase 5; ubiquitin-specific protease-5 (ubiquitin isopeptidase T); ubiquitin-specific-processing protease 5

Rabbit

IgG

Ubiquitin carboxyl-terminal hydrolase 5

Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored \Lys-48\-linked polyubiquitin disassembly. Binds linear and \Lys-63\-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.

Human

-20°C or -80°C

12352203