UT-34

MedChem Express

UT-34 [2168525-92-4]

10

2168525-92-4

Research Use Only

98.61

C15H12F4N4O2

356.27

UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor ( AR ) antagonist and degrader, with IC 50 values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR , F876L-AR , and W741L-AR , respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CN2N=CC(F)=C2

-20°C,2°C to 8°C

12352200