Utrophin antibody [DRP3/20C5]

GeneTex

Utrophin antibody [DRP3/20C5]

9

This antibody recognizes amino terminal domain of the human homolog of human dystrophin, utrophin.

IHC-Fr: 1:2-1:10. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Frozen

Research Use Only

Monoclonal

DRP3/20C5

Unconjugated

UTRN

utrophin

DMDL; DRP; DRP1; dystrophin-related protein 1; utrophin

Mouse

IgG1

Utrophin

This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

Canine, Human, Rat

-20°C or -80°C,2°C to 8°C

12352203