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ProductsBack/Uzansertib [1620012-39-6]
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Uzansertib [1620012-39-6]

Research Use Only
T39090
TargetMol Chemicals
CAS Number1620012-39-6
DownloadMSDS
Product group Chemicals
Molecular Weight513.521
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Overview

  • Supplier
    TargetMol Chemicals
  • Product Name
    Uzansertib [1620012-39-6]
  • Delivery Days Customer
    16
  • CAS Number
    1620012-39-6
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Chemical Name
    Uzansertib
  • Molecular Formula
    C26H26F3N5O3
  • Molecular Weight
    513.521
  • Scientific Description
    Uzansertib (INCB053914) is a potent ATP-competitive pan-PIM kinase inhibitor. It exhibits exceptional inhibitory activity against PIM1, PIM2, and PIM3 with IC50 values of 0.24 nM, 30 nM, and 0.12 nM, respectively. Furthermore, Uzansertib demonstrates significant anti-proliferative effects against an assorted range of hematologic tumor cell lines.
  • Shelf life instruction
    3 years
  • SMILES
    C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1c2CC[C@@H](O)c2ncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
  • Storage Instruction
    -20°C
  • UNSPSC
    12352200

References

  • Koblish H, et al. Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies. PLoS One. 2018 Jun 21;13(6):e0199108.
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