Varenicline (dihydrochloride)

MedChem Express

Varenicline (dihydrochloride) [866823-63-4]

10

866823-63-4

Research Use Only

99.21

C13H15Cl2N3

284.18

Varenicline (CP 526555-18) is an orally active partial agonist of alpha4beta2 nicotinic acetylcholine receptor (alpha4beta2 nAChR, IC 50 = 250 nM), which is the principal mediator of nicotine dependence. Varenicline is also a partial agonist of alpha6beta2 nAChR and a full agonist of alpha6beta2 nAChR . Varenicline blocks the direct agonist effects of nicotine on nAChR while stimulates nAChR in a more moderate way, being widely used as an aid of smoking cessation [1] [2] [3] [4] [5] .

[H]Cl.[H]Cl.C1(C2)CNCC2C3=CC4=NC=CN=C4C=C13

-20°C

12352200