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Vaspin (human) ELISA Kit

Research Use Only
AG-45A-0017YEK
AdipoGen Life Sciences
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Vaspin (human) ELISA Kit
  • Delivery Days Customer
    10
  • Applications
    ELISA
  • Assay Detection Range
    0.016 to 1ng/ml
  • Assay Sensitivity
    12pg/ml
  • Assay Specificity
    Detects human vaspin. Does not cross-react with human RBP4, human adiponectin, human Nampt, human leptin or human RELM-beta.
  • Certification
    Research Use Only
  • Scientific Description
    ELISA Assay. Detects human vaspin. Does not cross-react with human RBP4, human adiponectin, human Nampt, human leptin or human RELM-beta. Colorimetric assay. Sample Types: Cell Culture Supernatant, Plasma, Serum. Range: 0.016 to 1ng/ml. Sensitivity: 12pg/ml. Vaspin (Visceral adipose tissue-derived serpin; Serpin A12), a serine protease inhibitor (serpin), is an insulin-sensitizing adipocytokine that has been isolated from both visceral and subcutaneous white adipose tissue. Based on recent findings, vaspin is suggested to regulate immune responses and inflammation and was found to be correlated with various metabolic parameters. Human vaspin blood levels are significantly increased in type 2 diabetes mellitus and obese patients. Thus vaspin may represent a novel biomarker for obesity and impaired insulin sensitivity and might serve as a new therapeutic target of metabolic syndrome. - Vaspin (Visceral adipose tissue-derived serpin; Serpin A12), a serine protease inhibitor (serpin), is an insulin-sensitizing adipocytokine that has been isolated from both visceral and subcutaneous white adipose tissue. Based on recent findings, vaspin is suggested to regulate immune responses and inflammation and was found to be correlated with various metabolic parameters. Human vaspin blood levels are significantly increased in type 2 diabetes mellitus and obese patients. Thus vaspin may represent a novel biomarker for obesity and impaired insulin sensitivity and might serve as a new therapeutic target of metabolic syndrome.
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    41116158

References

  • Serum vaspin concentrations in human obesity and type 2 diabetes: B.S. Youn, et al.; Diabetes 57, 372 (2008)
  • Serum levels of the adipokine vaspin in relation to metabolic and renal parameters: J. Seeger, et al.; J. Clin. Endocrinol. Metab. 93, 247 (2008)
  • Metformin decreases the Adipokine Vaspin in overweight women with the polycystic ovary syndrome: Concomitant improvement in insulin sensitivity and a decrease in insulin resistance: B.K. Tan, et al.; Diabetes 57, 1501 (2008)
  • Vaspin: a novel serpin with insulin-sensitizing effects: J. Wada; Expert Opin. Investig. Drugs 17, 327 (2008)
  • Vaspin serum concentrations in patients with carotid stenosis: G. Aust, et al.; Atherosclerosis 204, 262 (2009)
  • Serum vaspin levels in type 2 diabetic women in relation to microvascular complications: N.E. Gulcelik, et al.; Eur. J. Endocrinol. 160, 65 (2009)
  • Serum Visceral Adipose Tissue–Derived Serine Protease Inhibitor Concentrations in Human Obesity and Polycystic Ovary Syndrome: H.F. Escobar-Morreale, et al.; Diabetes Care 32, e6 (2009)
  • Low-dose pioglitazone and low-dose flutamide added to metformin and oestro-progestagens for hyperinsulinaemic women with androgen excess: add-on benefits disclosed by a randomized double-placebo study over 24 months: L. Ibanez, et al.; Clin. Endocrinol. (Oxf) 71, 351 (2009)
  • Preliminary report: circulating levels of the adipokine vaspin in gestational diabetes mellitus and preeclampsia: H. Stepan, et al.; Metabolism 59, 1054 (2010)
  • Circadian Rhythm of Serum Vaspin in Healthy Male Volunteers: Relation to Meals: E. Jeong, et al.; J. Clin. Endocrinol. Metab. 95, 1869 (2010)