Neutralizing/Blocking assay analysis of mouse endothelial cells stimulated with mouse VEGFA for 20 mins in the absence or presence of GTX53467 VEGFA antibody [MAB0705]. The level of p-VEGFR2 was detected using anti-phospho-VEGF2.
Neutralizing/Blocking assay analysis of mouse endothelial cells stimulated with mouse VEGFA for 20 mins in the absence or presence of GTX53467 VEGFA antibody [MAB0705]. The level of p-VEGFR2 was detected using anti-phospho-VEGF2.
VEGFA antibody [MAB0705]
GTX53467
ApplicationsWestern Blot, Neutralisation/Blocking
Product group Antibodies
ReactivityHuman, Mouse
TargetVegfa
Overview
- SupplierGeneTex
- Product NameVEGF antibody [MAB0705] - Orthogonal Validated
- Delivery Days Customer9
- ApplicationsWestern Blot, Neutralisation/Blocking
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMAB0705
- ConjugateUnconjugated
- Gene ID22339
- Target nameVegfa
- Target descriptionvascular endothelial growth factor A
- Target synonymsV; vascular endothelial growth factor A; vascular permeability factor; Veg; Vegf; VEGF12; VEGF16; VEGF18; Vpf
- HostMouse
- IsotypeIgG1
- Protein IDQ00731
- Protein NameVascular endothelial growth factor A
- Scientific DescriptionThis gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203