VEGFR-2/DHFR-IN-1

MedChem Express

VEGFR-2/DHFR-IN-1

10

Research Use Only

C20H18ClNO4

371.81

VEGFR-2/DHFR-IN-1 (compound 8b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.384 and 7.881 microM, respectively. VEGFR-2/DHFR-IN-1 shows good antibacterial activities against Escherichia coli, Streptococcus faecalis, Salmonella enterica, MSSA and MRSA with MIC values of 16, 16, 16, 8, and 16 microg/mL, respectively. VEGFR-2/DHFR-IN-1 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 2.97-7.12 microM. VEGFR-2/DHFR-IN-1 can be used for the research of cancer[1].

O=C(NCC1=CC=C(Cl)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2

12352200