Vercirnon

MedChem Express

Vercirnon [698394-73-9]

10

698394-73-9

Research Use Only

98.26

C22H21ClN2O4S

444.93

Vercirnon (GSK1605786A) is an orally bioavailable, selective, and potent antagonist of CCR9 . Vercirnon inhibits CCR9-mediated Ca 2+ mobilization and chemotaxis on Molt-4 cells with IC 50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC 50 s>10 microM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC 50 values of 2.8 and 2.6 nM, respectively [1] .

O=S(C1=CC=C(C(C)(C)C)C=C1)(NC2=CC=C(Cl)C=C2C(C3=CC=[N+]([O-])C=C3)=O)=O

-20°C,2°C to 8°C

12352200