Versican Antibody: RPE

Biorbyt

Versican antibody

16

1 microg/ml of SMC-439 was sufficient for detection of Versican in 20 microg of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.

ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry

WB (1:1000), ICC/IF (1:100) ICC, IF, IHC, WB

Research Use Only

Monoclonal

N351/23 (Formerly sold as S351-23)

1 mg/ml

RPE

Vcan

versican

5430420N07Rik; 9430051N09; chondroitin sulfate proteoglycan core protein 2; Csp; Cspg2; DPE; DPEAAE; hdf; large fibroblast proteoglycan; NG2; PG-; PG-M; PG-M core protein; PG-M(V0); PG-M(V1); versican core protein

Mouse

IgG1

Versican core protein

Mouse monoclonal to Versican (RPE). Versican (chondroitin sulfate proteoglycan 2) is a large extracellular matrix proteoglycan involved in cell growth and differentiation. Important as a structural molecule, versican creates loose and hydrated matrices during key events in development and disease. The protein contains hyaluronic acid and glycosminoglycan-binding domains, epidermal growth factor-like repeats, a Lectinlike sequence and a complement regulatory protein-like domain. Splice variants differ greatly in length and degree of modification by glycoaminoglycan chains. Accumulation around smooth muscle cells in lesions of athero-sclerosis suggests a role for versican in atherogenesis. Versican, differentially expressed in human melanoma, plays a role in tumor development and may be a reliable marker for clinical diagnosis. The organization of HA- and versican-rich pericellular matrices may faciliatate migration and mitosis by diminishing cell surface adhesivity and affecting cell shape through steric exclusion and the viscous properties of HA proteoglycan gels..

Human, Mouse, Rat

See Manual

12352203