VH298

Selleck Chemicals

VH298

9

Research Use Only

VH298 is a potent VHL (Von Hippel-Lindau, the E3 ligase) inhibitor that stabilizes HIF-alfa. VH298 blocks the VHL:HIF-alfa interaction with Kd of 90 nM in isothermal titration calorimetry (ITC) and 80 nM in a competitive fluorescence polarization assay. VH-298 can be used in PROTAC technology.

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