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ProductsBack/Vinculin antibody [N1N3]

Vinculin antibody [N1N3]

GTX113294
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetVCL
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Overview

  • Supplier
    GeneTex
  • Product Name
    Vinculin antibody [N1N3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.67 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID7414
  • Target name
    VCL
  • Target description
    vinculin
  • Target synonyms
    CMD1W; CMH15; epididymis luminal protein 114; epididymis secretory sperm binding protein; HEL114; metavinculin; meta-vinculin; MV; MVCL; vinculin; vinculin isoform meta-VCL
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP18206
  • Protein Name
    Vinculin
  • Scientific Description
    Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

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  • NDUFS3 depletion permits complex I maturation and reveals TMEM126A/OPA7 as an assembly factor binding the ND4-module intermediate. DAngelo L et al., 2021 Apr 20, Cell Rep
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  • Evidence of enteric angiopathy and neuromuscular hypoxia in patients with mitochondrial neurogastrointestinal encephalomyopathy. Boschetti E et al., 2021 May 1, Am J Physiol Gastrointest Liver Physiol
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  • Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance. Inder S et al., 2019 Nov 22, Sci Rep
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  • Gut epithelial and vascular barrier abnormalities in patients with chronic intestinal pseudo-obstruction. Boschetti E et al., 2019 Aug, Neurogastroenterol Motil
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  • Differential expression of PKCalpha and -beta in the zebrafish retina. Haug MF et al., 2019 Jun, Histochem Cell Biol
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  • Chemical proteomics identifies heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as the molecular target of quercetin in its anti-cancer effects in PC-3 cells. Ko CC et al., 2014 Aug 8, J Biol Chem
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  • Substrate stiffness regulates filopodial activities in lung cancer cells. Liou YR et al., 2014, PLoS One
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