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ProductsBack/(-)-Viriditoxin [1381782-08-6]
Chemical Structure
Chemical Structure
Chemical Structure

(-)-Viriditoxin [1381782-08-6]

Research Use Only
AG-CN2-0471
AdipoGen Life Sciences
CAS Number1381782-08-6
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight662.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    (-)-Viriditoxin [1381782-08-6]
  • Delivery Days Customer
    10
  • CAS Number
    1381782-08-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Warning
  • Molecular Formula
    C34H30O14
  • Molecular Weight
    662.6
  • Scientific Description
    Antibiotic. Exhibits broad activity against Gram-positive bacteria. Bacterial cell division protein FtsZ inhibitor (IC50=8.2microg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0microg/ml). Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells. Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria. - Chemical. CAS: 1381782-08-6. Formula: C34H30O14. MW: 662.6. Isolated from fungus Aspergillus sp. Antibiotic. Exhibits broad activity against Gram-positive bacteria. Bacterial cell division protein FtsZ inhibitor (IC50=8.2microg/ml). Inhibits the GTPase activity of FtsZ in vitro (IC50=7.0microg/ml). Induces apoptosis and autophagy and inhibits cell growth at G2/M in human prostate cancer cells. Activates ATP hydrolysis and induces calcium sensitized swelling of rat liver mitochondria.
  • SMILES
    COC(=O)C[C@@H]1CC2=CC3=C(C(O)=CC(OC)=C3C3=C4C=C5C[C@@H](CC(=O)OC)OC(=O)C5=C(O)C4=C(O)C=C3OC)C(O)=C2C(=O)O1
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Viriditoxin production by Aspergillus viridi-nutans and related species: E.B. Lillehoj & M.S. Milburn; Appl. Microbiol. 26, 202 (1973)
  • Metabolic products from Spicaria divaricata NRRL 5771: J. Jiu S. Mizuba; J. Antibiot. (Tokyo) 27, 760 (1974)
  • Viriditoxin induces swelling and atpase by activation of calcium transport in liver mitochondria: D.T. Wong & R.L. Hamill; BBRC 71, 332 (1976)
  • Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics: J. Wang, et al.; J. Biol. Chem. 278, 44424 (2003)
  • Second-Generation Synthesis of (-)-Viriditoxin: C.I. Grove & J.T. Shaw; Synthesis 2012, 362 (2012)
  • Viriditoxin regulates apoptosis and autophagy via mitotic catastrophe and microtubule formation in human prostate cancer cells: S. Kundu, et al.; Int. J. Oncol. 45, 2331 (2014)
  • A twist of nature - the significance of atropisomers in biological systems: J.E. Smyth, et al.; Nat. Prod. Rep. 32, 1562 (2015)