VNPP433-3beta

MedChem Express

VNPP433-3beta

5

Research Use Only

98.01

C29H34N4

438.61

VNPP433-3beta is a molecular glue degrader, which degrades androgen receptor (AR) and its splice variants (AR-Vs) and MAP kinase-interacting serine/threonine protein kinase Mnk1/2. VNPP433-3beta inhibits proliferation of cancer cell LNCaP, C4-2B and CWR22Rv1 with GI50 of 0.2, 0.3 and 0.31 microM. VNPP433-3beta exhibits good pharmacokinetic characters in CD-1 mouse and inhibits tumor growth in the CWR22Rv1 xenograft mouse model[1].

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2°C to 8°C

12352200