VU0360172 (hydrochloride)

MedChem Express

VU0360172 (hydrochloride) [1309976-62-2]

14

1309976-62-2

Research Use Only

C18H16ClFN2O

330.78

VU0360172 hydrochloride is a potent and selective mGlu5 receptor positive allosteric modulator (PAM) with an EC 50 value of 16 nM and a K i of 195 nM, respectively. VU0360172 hydrochloride stimulates polyphosphoinositide (PI) hydrolysis in vivo , which is abrogated in mGlu5 receptors gene deleted mice [1] .

O=C(C1=CN=C(C=C1)C#CC2=CC(F)=CC=C2)NC3CCC3.Cl

12352200