VU0364770 [61350-00-3]

MedChem Express

VU0364770 [61350-00-3]

10

61350-00-3

Research Use Only

99.93

C12H9ClN2O

232.67

VU0364770 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 exhibits EC50s of 290 nM and 1.1 microM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 exhibits antagonist activity at mGlu5 with a potency of 17.9 microM and PAM activity at mGlu6 with a potency of 6.8 microM. VU0364770 also possesses activity at MAO with Ki values of 8.5 and 0.72 microM for human MAO-A and human MAO-B, respectively[1].

O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2

-20°C,2°C to 8°C

12352200