VU0364770 (hydrochloride)

MedChem Express

VU0364770 (hydrochloride) [1414842-70-8]

10

1414842-70-8

99.70

C12H10Cl2N2O

269.13

VU0364770 hydrochloride is a selective and potent positive allosteric modulator ( PAM ) of mGlu4 . VU0346770 hydrochloride exhibits EC 50 s of 290 nM and 1.1 microM at rat mGlu4 and human mGlu4 receptor , respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 microM and PAM activity at mGlu6 with a potency of 6.8 microM. VU0364770 hydrochloride also possesses activity at MAO with K i values of 8.5 and 0.72 microM for human MAO-A and human MAO-B, respectively [1] .

O=C(C1=NC=CC=C1)NC2=CC=CC(Cl)=C2.[H]Cl

2°C to 8°C

12352200