VU0448088 [1417616-42-2]

TargetMol Chemicals

VU0448088 [1417616-42-2]

9

Research Use Only

C16H15ClN4OS

346.83

VU0448088 (ML253) is a potent positive allosteric modulator of the tricyclic muscarinic acetylcholine receptor subtype 4 (M4) and can cross the blood-brain barrier. It exhibits EC50 values of 56 nM and 176 nM in humans and rats, respectively. The compound VU0448088 holds potential for use in psychiatric research.

O=C(NCC=1C=CN=CC1)C=2SC3=NC(=C(Cl)C(=C3C2N)C)C

-20°C

12352200