VUF10166

MedChem Express

VUF10166 [155584-74-0]

10

155584-74-0

Research Use Only

99.83

C13H15ClN4

262.744

VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 microM[1].

CN1CCN(C2=NC3=CC=CC=C3N=C2Cl)CC1

2°C to 8°C

12352200