VVD-214

MedChem Express

VVD-214

5

Research Use Only

99.76

C20H21F2N3O4S

437.46

VVD-214 is a synthetic lethal allosteric inhibitor of WRN helicase with an IC 50 of 0.1316 microM. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers [1] [2] .

CS(/C=C/[C@H](C1CC1)NC(C(C(OC2=CC=CC=C2)=N3)=CN=C3C(F)(F)C)=O)(=O)=O

-20°C,2°C to 8°C

12352200