Bio-Connect

WBSCR22 antibody

GTX105840
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetBUD23
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Overview

  • Supplier
    GeneTex
  • Product Name
    WBSCR22 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:500-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.42 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID114049
  • Target name
    BUD23
  • Target description
    BUD23 rRNA methyltransferase and ribosome maturation factor
  • Target synonyms
    bud site selection protein 23 homolog; HASJ4442; HUSSY-3; MERM1; metastasis-related methyltransferase 1; PP3381; probable 18S rRNA (guanine-N(7))-methyltransferase; ribosome biogenesis methyltransferase WBSCR22; rRNA methyltransferase and ribosome maturation factor; WBMT; WBSCR22; Williams-Beuren candidate region putative methyltransferase; Williams-Beuren syndrome chromosomal region 22 protein; Williams-Beuren syndrome chromosome region 22
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO43709
  • Protein Name
    Probable 18S rRNA (guanine-N(7))-methyltransferase
  • Scientific Description
    This gene encodes a protein containing a nuclear localization signal and an S-adenosyl-L-methionine binding motif typical of methyltransferases, suggesting that the encoded protein may act on DNA methylation. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • WBSCR22 Competes with Long Non-coding RNA Linc00346 for miR-509-5p Binding Site to Regulate Cancer Stem Cell Phenotypes of Colorectal Cancer. Zhao H et al., 2020 Jun, Biochem Genet
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  • Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Baxter M et al., 2020 Jan 15, Elife
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  • Natural killer cells inhibit oxaliplatin-resistant colorectal cancer by repressing WBSCR22 via upregulating microRNA-146b-5p. Zhao H et al., 2018, Am J Cancer Res
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  • The novel metastasis promoter Merm1/Wbscr22 enhances tumor cell survival in the vasculature by suppressing Zac1/p53-dependent apoptosis. Nakazawa Y et al., 2011 Feb 1, Cancer Res
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