WDR24 antibody
GTX133576
Overview
- SupplierGeneTex
- Product NameWDR24 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration4.38 mg/ml
- ConjugateUnconjugated
- Gene ID84219
- Target nameWDR24
- Target descriptionWD repeat domain 24
- Target synonymsC16orf21; GATOR complex protein WDR24; JFP7; WD repeat-containing protein 24
- HostRabbit
- IsotypeIgG
- Protein IDQ96S15
- Protein NameGATOR complex protein WDR24
- Scientific DescriptionAs a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:23723238, PubMed:27166823). Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 (PubMed:26449471, PubMed:26586190, PubMed:27487210). In addition to its role in regulation of the TORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux (PubMed:27166823).
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203