WH-10417-099

MedChem Express

WH-10417-099

10

Research Use Only

98.14

C52H62N8O13S

1039.16

WH-10417-099 is a CRBN-type PROTAC multi-kinase degrader that can jointly induce the degradation of the largest number of unique kinases (more than 125 unique kinases). WH-10417-099 induces protein degradation through the ubiquitin biotinylation (E-STUB) pathway and consists of the target protein ligand (red part) PI3Kgamma ligand 1 (HY-168319), the E3 ubiquitin ligase ligand (blue part) Thalidomide 4-fluoride (HY-41547) and the PROTAC linker (black part) Amino-PEG5-C2-acid (HY-115384). The E3 ligase ligand and linker can form a conjugate Pomalidomide 4-PEG5-acid (HY-131647).

O=C1N(C2CCC(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCOCCC(NCCCN(C4CC4)S(C5=CC=C(C6=CN=C(N)C(C7=CC(CCNC8=O)=C8C=C7)=C6)C=C5)(=O)=O)=O)=O

-20°C,2°C to 8°C

12352200