WH244 [2941088-96-4]

TargetMol Chemicals

WH244 [2941088-96-4]

9

Research Use Only

C83H105ClF3N13O11S4

1681.51

WH244 is a second-generation dual degrader (PROTAC) targeting BCL-2 and BCL-xL proteins. It effectively degrades these proteins with high specificity, exhibiting a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2. By promoting ubiquitination and subsequent proteasomal degradation of these proteins, WH244 restores apoptotic pathways in cells. The compound shows strong antitumor activity. (Pink: BCL-2/BCL-xL ligand; Blue: E3 ligase ligand; Black: linker).

C(C1=C(CC[C@](CN2CCN(C(CN3CCN(CC(N[C@H](C(=O)N4[C@H](C(N[C@@H](C)C5=CC=C(C=C5)C6=C(C)N=CS6)=O)C[C@@H](O)C4)[C@@](C)(C)C)=O)CC3)=O)CC2)(C)C1)C7=CC=C(Cl)C=C7)N8CCN(CC8)C9=CC=C(C(NS(=O)(=O)C%10=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN%11[C@@]%12(C[C@](C%11)(OC%12)[H])[H])CSC%13=CC=CC=C%13)C=C%10)=O)C=C9

-20°C

12352200