Wilms tumor protein/WT1 Protein, Human, Recombinant (His & SUMO)

TargetMol Chemicals

Wilms tumor protein/WT1 Protein, Human, Recombinant (His & SUMO)

16

Research Use Only

65.2 kDa (predicted)

Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.

-20°C

12352200