WK298

MedChem Express

WK298

9

Research Use Only

C35H38Cl2N6O

629.62

WK298 is a potent inhibitor of the MDM2/MDMX-p53 interaction with good anti-tumor activity. WK298 can fully activate the p53 pathway by inhibiting the binding of MDM2 and MDMX to p53. The development of WK298 benefited from a deep understanding of the key elements of the p53-MDM2/MDMX interaction structure [1] .

O=C(N1C[C@H](CC1)N(C)CCCN(C)C)C2=C(C3=C(C4=CC=CC=C4)N=CN3CC5=CC=C(C=C5)Cl)C6=CC=C(Cl)C=C6N2

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