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ProductsBack/Wogonin [632-85-9]
Chemical Structure
Chemical Structure
Chemical Structure

Wogonin [632-85-9]

Research Use Only
AG-CN2-0064
AdipoGen Life Sciences
CAS Number632-85-9
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Product group Chemicals
Estimated Purity>98%
Molecular Weight284.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Wogonin [632-85-9]
  • Delivery Days Customer
    10
  • CAS Number
    632-85-9
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Molecular Formula
    C16H12O5
  • Molecular Weight
    284.3
  • Scientific Description
    Anti-inflammatory. Increases nitric oxide (NO) production [1]. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II) [2, 5]. Antioxidant [3]. Anti-viral. Shows anti-hepatitis B virus activity [4]. MCP-1 inhibitor [6]. Shows anxiolytic effect through modulation of the GABA(A) receptor complex [7]. Antifungal [8]. Neuroprotective [9]. Anticancer compound. Apoptosis and cell cycle arrest inducer [10, 12, 14, 17, 18]. Sensitizes TNFalpha- and TRAIL-induced apoptosis [11, 12]. Antiangiogenic [13]. NF-kappaB inhibitor [15]. Telomerase activity inhibitor [16]. CDK9 inhibitor [19]. PI3K-AKT pathway modulator [20]. Autophagy inducer [21]. - Chemical. CAS: 632-85-9. Formula: C16H12O5. MW: 284.3. Isolated from Scutellaria baicalensis Georgi. Anti-inflammatory. Increases nitric oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer.
  • SMILES
    COC1=C(O)C=C(O)C2=C1OC(=CC2=O)C1=CC=CC=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Inhibitory effects of baicalein and wogonin on lipopolysaccharide-induced nitric oxide production in macrophages: I. Wakabayashi; Pharmacol. Toxicol. 84, 288 (1999)
  • Wogonin inhibits inducible prostaglandin E(2) production in macrophages: I. Wakabayashi & K. Yasui; Eur. J. Pharmacol. 406, 477 (2000)
  • Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin: D.E. Shieh, et al.; Anticancer Res. 20, 2861 (2000)
  • Anti-hepatitis B virus effects of wogonin isolated from Scutellaria baicalensis: R.L. Huang, et al.; Planta Med. 66, 694 (2000)
  • Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide: Y.C. Chen, et al.; Biochem. Pharmacol. 61, 1417 (2001)
  • Chinese herbal remedy wogonin inhibits monocyte chemotactic protein-1 gene expression in human endothelial cells: Y.L. Chang, et al.; Mol. Pharmacol. 60, 507 (2001)
  • Anxiolytic effect of wogonin, a benzodiazepine receptor ligand isolated from Scutellaria baicalensis Georgi: K.M. Hui, et al.; Biochem. Pharmacol. 64, 1415 (2002)
  • Antifungal activity of wogonin: M. Pal, et al.; Phytother. Res. 17, 1215 (2003)
  • Neuroprotective effect of wogonin: potential roles of inflammatory cytokines: H.Z. Piao, et al.; Arch. Pharm. Res. 27, 930 (2004)
  • The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo: W. Wang, et al.; Biol. Pharm. Bull. 29, 1132 (2006)