WRX606

MedChem Express

WRX606

5

Research Use Only

95.65

C28H25ClN4O6

548.97

WRX606 is an inhibitor for mTOR complex 1 ( mTORC1 ). WRX606 inhibits the phosphorylation of mTORC1 substrate S6 kinase 1 S6K1 ( IC 50 =10 nM), and the phosphorylation of the eukaryotic translation initiation factor 4E binding protein (p-4E-BP1) ( IC 50 =0.27 microM) in MCF-7. WRX606 exhibits cytotoxicity to HepG2 with IC 50 of 17 nM. WRX606 exhibits antitumor efficacy in mouse models [1] .

O=C(CN1C(N(CCCC(NCC2=CC=C3OCOC3=C2)=O)C(C4=C1C=CC=C4)=O)=O)NC5=CC(Cl)=CC=C5

2°C to 8°C

12352200