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ProductsBack/Xanthorrhizol [30199-26-9]
Chemical Structure
Chemical Structure
Chemical Structure

Xanthorrhizol [30199-26-9]

Research Use Only
AG-CN2-0090
AdipoGen Life Sciences
CAS Number30199-26-9
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Product group Chemicals
Estimated Purity>97%
Molecular Weight218.3
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Xanthorrhizol [30199-26-9]
  • Delivery Days Customer
    10
  • CAS Number
    30199-26-9
  • Certification
    Research Use Only
  • Estimated Purity
    >97%
  • Hazard Information
    Danger
  • Molecular Formula
    C15H22O
  • Molecular Weight
    218.3
  • Scientific Description
    Chemical. CAS: 30199-26-9. Formula: C15H22O. MW: 218.3. Isolated from Curcuma xanthorrhiza. Shows calcium-antagonistic and vasorelaxant activity. Antibacterial. Anti-inflammatory. Potent COX-2 and inducible nitric oxide (iNOS; NOS II) inhibitor. Hepatoprotective. Anticancer compound. Apoptosis inducer. Neuroprotective antioxidant. Antifungal. - Shows calcium-antagonistic and vasorelaxant activity [1,3]. Antibacterial [2]. Anti-inflammatory. Potent COX-2 and inducible nitric oxide (iNOS; NOS II) inhibitor [4,5,9]. Hepatoprotective [5, 6]. Anticancer compound. Apoptosis inducer [7,8,10,12]. Neuroprotective antioxidant [8]. Antifungal [11].
  • SMILES
    C[C@H](CCC=C(C)C)C1=CC=C(C)C(O)=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Effect of xanthorrhizol, xanthorrhizol glycoside and trachylobanoic acid isolated from Cachani complex plants upon the contractile activity of uterine smooth muscle: H. Ponce-Monter, et al.; Phytother. Res. 13, 202 (1999)
  • Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens: J.K. Hwang, et al.; Fitoterapia 71, 321 (2000)
  • Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta: M.G. Campos, et al.; Life Sci. 67, 327 (2000)
  • Suppressive effect of natural sesquiterpenoids on inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) activity in mouse macrophage cells: S.K. Lee, et al.; J. Environ. Pathol. Toxicol. Oncol. 21, 141 (2002)
  • Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcription: S.H. Kim, et al.; Toxicol. Appl. Pharmacol. 196, 346 (2004)
  • Phosphorylation of c-Jun N-terminal Kinases (JNKs) is involved in the preventive effect of xanthorrhizol on cisplatin-induced hepatotoxicity: K.O. Hong, et al.; Arch. Toxicol. 79, 231 (2005)
  • Xanthorrhizol induces apoptosis via the up-regulation of bax and p53 in HeLa cells: N. Ismail, et al.; Anticancer Res. 25, 2221 (2005)
  • Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia: C.S. Lim, et al.; J. Neurosci. Res. 82, 831 (2005)
  • Regulation of p53-, Bcl-2- and caspase-dependent signaling pathway in xanthorrhizol-induced apoptosis of HepG2 hepatoma cells: T. Handayani, et al.; Anticancer Res. 27, 965 (2007)
  • Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-acti: W.Y. Chung, et al.; Carcinogenesis 28, 1224 (2007)