Yangambin

MedChem Express

Yangambin [13060-14-5]

10

13060-14-5

Research Use Only

98.27

C24H30O8

446.49

Yangambin, a furofuran lignan, is already isolated from plants such as member of the Annonaceae family, including species of the genus Rollinia: R. pickeli, R. exalbidaand R. mucosa, as well from the Magnolia biondii. Yangambin, a selective PAF receptor antagonist, inhibits Ca2+ influx through voltage-gated Ca2+ channels, leading to the reduction in [Ca2+]i in vascular smooth muscle cells and consequent peripheral vasodilation[1]. Yangambin exhibits the antiallergic activity against beta-hexosaminidase release with an IC50 of 33.8 microM and for anti-inflammatory activity with an IC50 of 37.4 microM[2].

COC1=C(OC)C(OC)=CC([C@H]2OC[C@]3([H])[C@@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[C@@]32[H])=C1

2°C to 8°C

12352200