YJ1206

MedChem Express

YJ1206

9

Research Use Only

96.36

C49H52FN11O5

894.01

YJ1206 is an orally active, selective CDK12/CDK13 PROTAC degrader with an IC 50 of 12.55 nM for in VCaP cells. YJ1206 increases DNA damage, induces apoptosis , and promotes tumor regression in orthotopic WA74 patient-derived xenograft (PDX) mice models of resistant prostate cancer. YJ1206 suppresses tumor growth in vivo in conjunction with AKT pathway inhibitors. YJ1206 is composed of the CDK12/CDK13 degradation agent (HY-168658), a linker (HY-W004328), and a VHL E3 ubiquitin ligase (HY-W453548). (Pink: Navitoclax; Blue: VHL ligand; Black: linker) [1] .

O=C(NCC1=CC=CC=C1)N(C2=CN=C(N3CCN(C4CCN(C5=C(F)C=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=C5)CC4)CC3)C=C2)[C@H](CC8)CC[C@@H]8NC9=NC=C%10C(C=CC=C%10)=N9

-20°C

12352200