YKL-5-124 (TFA)
HY-101257B
Overview
- SupplierMedChem Express
- Product NameYKL-5-124 (TFA)
- Delivery Days Customer10
- Estimated Purity99.74
- Molecular FormulaC30H34F3N7O5
- Molecular Weight629.63
- Scientific DescriptionYKL-5-124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC 50 s of 53.5 nM and 9.7 nM for CDK7 and CDK7/Mat1/CycH , respectively. YKL-5-124 TFA is >100-fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL-5-124 TFA induces a strong cell-cycle arrest, inhibits E2F-driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status [1] .
- SMILESCC1(C)N(C(N[C@@H](C2=CC=CC=C2)CN(C)C)=O)CC3=C1NN=C3NC(C4=CC=C(NC(C=C)=O)C=C4)=O.FC(F)(C(O)=O)F
- Storage Instruction2°C to 8°C
- UNSPSC12352200