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ProductsBack/YM-244769 (dihydrochloride) [1780390-65-9]

YM-244769 (dihydrochloride) [1780390-65-9]

HY-136182
MedChem Express
CAS Number1780390-65-9
DownloadMSDS
Product group Chemicals
Estimated Purity98.57
Molecular Weight516.39
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Overview

  • Supplier
    MedChem Express
  • Product Name
    YM-244769 (dihydrochloride) [1780390-65-9]
  • Delivery Days Customer
    10
  • CAS Number
    1780390-65-9
  • Certification
    Research Use Only
  • Estimated Purity
    98.57
  • Molecular Formula
    C26H24Cl2FN3O3
  • Molecular Weight
    516.39
  • Scientific Description
    YM-244769 dihydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 dihydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 dihydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 dihydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3].
  • SMILES
    O=C(C1=CC=C(OC2=CC=C(OCC3=CC=CC(F)=C3)C=C2)N=C1)NCC4=CC=CC(N)=C4.Cl.Cl
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703

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YM-244769 dihydrochlorideORB2279932
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YM-244769 dihydrochloride [1780390-65-9]
Product group Chemicals
TargetMol Chemicals
YM-244769 dihydrochloride [1780390-65-9]T39195
CAS Number1780390-65-9
Molecular Weight516.39
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