YM-355179 (fumarate)
HY-111198
Molecular Weight618.65
Product group Chemicals
Overview
- SupplierMedChem Express
- Product NameYM-355179 (fumarate)
- Delivery Days Customer9
- CertificationResearch Use Only
- Molecular FormulaC33H35FN4O7
- Molecular Weight618.65
- Scientific DescriptionYM-355179 fumarate is a newly synthesized selective CCR3 antagonist with the potential to inhibit eosinophil-related allergic inflammatory diseases. YM-355179 can effectively inhibit the binding of CCL11 and CCL5 to CCR3-expressing cells, with IC 50 values of 7.6 nM and 24 nM respectively. In functional experiments, YM-355179 can inhibit CCL11-induced intracellular Ca(2+) influx, chemotaxis and eosinophil degranulation, IC 50 The values are 8.0 nM, 24 nM and 29 nM respectively [1] .
- SMILESO=C(N[C@H]1CN(CC2=CC=C3C=C(F)C=CC3=C2)CC1)/C=C4CCN(C(C5=NC=C(C)C=C5O)=O)CC\4.O=C(O)/C=C/C(O)=O
- UNSPSC12352200