YUKA1

MedChem Express

YUKA1 [708991-09-7]

10

708991-09-7

99.56

C13H16N4O2S

292.36

YUKA1 is a potent and cell permeable Lysine demethylase 5A ( KDM5A ) inhibitor, with an IC 50 of 2.66 microM, less active on KDM5C (IC 50 , 7.12 microM), and is inactive on KDM5B, KDM6A or KDM6B. YUKA1 increases H3K4me3 levels in human cells with anti-cancer activity [1] .

C=CCOC1=C(CNN2C(NN=C2)=S)C=CC=C1OC

2°C to 8°C

12352200