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ProductsBack/Z-Leu-Leu-Leu-B(OH)2 [MG-262] [179324-22-2]
Chemical Structure
Chemical Structure
Chemical Structure

Z-Leu-Leu-Leu-B(OH)2 [MG-262] [179324-22-2]

Research Use Only
AG-CP3-0024
AdipoGen Life Sciences
Estimated Purity>95% (HPLC)
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Product group Chemicals
Molecular Weight491.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Z-Leu-Leu-Leu-B(OH)2 [MG-262] [179324-22-2]
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95% (HPLC)
  • Hazard Information
    Non-hazardous
  • Molecular Formula
    C25H42BN3O6
  • Molecular Weight
    491.4
  • Scientific Description
    Chemical. CAS: 179324-22-2. Formula: C25H42BN3O6. MW: 491.4. Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 (AG-CP3-0011) but much higher potency. - Highly potent and selective cell permeable inhibitor of the proteasome. Inhibits the chymotrypsin-like and caspase-like peptidase activity of the proteasome. Calpain and cathepsin inhibitor. Autophagy activator. Similar structure as MG-132 (AG-CP3-0011) but much higher potency.
  • SMILES
    CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1)B(O)O
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200

References

  • Down-regulation of Flt-1 gene expression by the proteasome inhibitor MG262: J. Mezquita, et al.; J. Cell. Biochem. 89, 1138 (2003)
  • Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate: A.F. Kisselev, et al.; J. Biol. Chem. 281, 8582 (2006)
  • Identification of the proteasome inhibitor MG262 as a potent ATP-dependent inhibitor of the Salmonella enterica serovar Typhimurium Lon protease: H. Frase, et al.; Biochemistry 45, 8264 (2006)
  • Characterization of the Physiological Turnover of Native and Inactivated Cytochromes P450 3A in Cultured Rat Hepatocytes: A Role for the Cytosolic AAA ATPase p97?: S. Faouzi, et al.; Biochemistry 46, 7793 (2007)
  • Proteasome activity and autophagosome content in liver are reciprocally regulated by ethanol treatment: P.G. Thomes, et al.; BBRC 417, 262 (2012)